Inhaling pure oxygen could keep your brain younger for longer

I’m hoping the Israeli’s will save us. We need our wits till the end.

Neuroscientists in Israel are trying to turn back the biological clock with one simple ingredient: oxygen

A (pricey) breath of fresh air for anti-aging research.

Patients take part in a hyperbaric oxygen therapy trial in Israel.

Patients take part in hyperbaric oxygen therapy in Israel. Many showed increased cognitive response after a six-month trial.

A heat map of brain activity prior to after therapy

No matter how much retinol cream and hair dye we slather on our faces and roots, we’ll all succumb to age eventually. There’s no cure for it, and it’s much more than skin-deep—aging takes a severe toll on our neurological well-being. Although biologists recently discovered how to reprogram the molecular processes of aging in yeast cells, we haven’t yet cracked the mysteries behind aging in the human brain.

Nearly 16 million people in the US struggle with cognitive impairment, a debilitating condition that eventually robs individuals of their independence by chipping away at their memory, motor functions, and ability to concentrate or learn.

But neuroscientists in Israel are trying to turn back the biological clock with one simple ingredient: oxygen. Shai Efrati, a physician and director of the Sagol Center for Hyperbaric Medicine and Research at the Yitzhak Shamir Medical Center in Israel, has developed a new type of hyperbaric oxygen therapy that increases blood flow in the brain to prevent declining cognitive function in the brains of healthy, older adults. His team’s results were published in the journal Aging this month.

Hyperbaric oxygen therapy involves breathing in pure, highly concentrated, oxygen in a pressurized chamber for a long duration, allowing a person’s lungs to collect three times the normal amount of oxygen from air. With elevated blood-oxygen levels, body tissues supposedly heal at increased rates by stimulating the formation of new vesselsat sites of injury. Historically, doctors have used the therapy to treat carbon monoxide poisoning, skin burns, traumatic brain injuries caused by strokes, and gas embolism, a condition that impacts deep-sea divers when nitrogen bubbles form in the circulatory system. More recently, hyperbaric oxygen therapy has been advertised as an all-encompassing treatment for many diseases—though the FDA emphasizes that the therapy hasn’t been clinically proven to treat cancer, diabetes, and autism.null

In this recent study, Efrati tested the therapy on normally aging adults without preexisting conditions to improve their cognitive function. For three months, 63 adults aged 65 and older spent five days a week, two hours a day in a pressurized chamber, breathing in concentrated oxygen at twice the amount of pressure as that of the Earth’s atmosphere. By the end of the study, Efrati discovered that blood flow in the brain increased. Frequent cognitive assessments also revealed that patients scored much higher on attention and information-processing speed tests than prior to the experiment.The study results showed an uptick in blood flow and oxygen levels in certain regions after the hyperbaric oxygen therapy. The Sagol Center for Hyperbaric Medicine and Research

Here’s how the researchers say it works. By dramatically raising blood-oxygen levels in aging patients, Efrati harnessed oxidative stress to prompt some brain cells to go into survivalist mode. Oxygen atoms are free radicals—at concentrated amounts, they scour the body, damaging DNA, cells, and proteins in a phenomenon called oxidative stress. “These short periods of high oxygen actually impose a mild beneficial stress on cells in the brain,” says Mark Mattson, a professor of neuroscience at Johns Hopkins University. This pressure might promote neurogenesis, a process in which stem cells form new neurons and brain cells, essentially making the central processing unit look and run “younger.” Exercise and intermittent fasting invoke similar reactions in the brain, Mattson says, without extreme adverse impacts.

It’s not just about raising oxygen levels, however: Fluctuation is also key. During the study, Efrati instructed patients to keep oxygen masks on for 20 minutes, then remove them for five-minute breaks. “You put the mask on and breathe 100 percent oxygen,” says Alexander Alvarez, a physician at Aviv Clinics, who administers hyperbaric oxygen therapy. “Then, when you take off the mask, the body thinks it’s in trouble.” Patients must spend at least two hours, five days a week in the oxygenation chamber at Aviv Clinics.

Efrati thinks that stress caused by fluctuating oxygen levels in the blood might stimulate stem cell growth. But this chain of events hasn’t been scientifically proven yet, says Uri Ashery, a professor of neuroscience at the Sagol School of Neuroscience in Israel. “The mechanisms behind hyperbaric oxygen therapy are unknown,” he notes. When asked if increased blood flow means more brain activity, as indicated in the study, Ashery also hesitated. “Not necessarily,” he says. “It can allow the brain to be more active since it brings in new oxygen. But it doesn’t always mean the brain is more active.”

But what about the patients’ high scores on cognitive assessments after the treatment? While there’s no direct evidence of stem cell proliferation, the study participants exhibited better short term memory, longer attention spans, and the ability to process information at faster speeds than before. Cognitive performance peaked after 20 treatments, Alvarez says, and remained elevated six months after therapy. It did drop off eventually—and scientists still aren’t sure how long the effects last. The treatment doesn’t last forever, Ashery explains, and its longevity depends on each individual’s genetics and lifestyle.

Despite those caveats, the waiting list for the hyperbaric oxygen therapy at the Florida-based company Aviv Clinics is already starting to grow, says CEO Dave Globig. Despite the onset of the COVID-19 pandemic, adults 55 years of age and older have been scrambling to get appointments since the treatment was first rolled out in mid-June. While most clients come from the Villages, a sprawling retirement community that hems the clinic, Globig anticipates taking on patients coming from all over the world. Each treatment package costs $60,000 and spans sixty days, requiring individuals to commute to the clinic five times a week for two-hour sessions.

After their 60 days are up, patients will continue to be monitored with a wearable medical device. If their cardiovascular or cognitive health declines, they’ll be invited back for a physical test and perhaps another round of hyperbaric oxygen therapy, Alvarez says.

Ashery hopes that one day the treatment might be popularized enough that it becomes accessible for more populations. “This is something that the government could invest in,” he says. “The scientific and medical communities show that it is quite helpful and prevents a lot of care later on, so this could easily become part of our regular treatment for older adults.”

Efrati, meanwhile, dreams of an aging community that’s completely independent and well-functioning. Longevity isn’t enough—a high quality of life is what these neuroscientists strive for. “We will all die someday,” Efrati says. “But we want to die when we are functioning. We want to go down with our heads up, not when we are debilitated.”

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Eliot and his new Meerkats friends

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The Economist Explains Why People Reject Vaccines


Throughout the United States, covid-19 is spreading rapidly, mostly owing to the highly contagious Delta variant. This fourth wave of infections is strongest in the heartland and southern states: cases per 100,000 people are highest in Arkansas, Florida and Louisiana; Missouri has the highest hospitalisations.

Identifying the causes of vaccine hesitancy can help policymakers decide where to target their efforts. According to surveys and modelling by The Economist, the single greatest predictor of whether an American has been vaccinated is whether they voted for Joe Biden or Donald Trump last November.

In many middle-income countries around the world, from Brazil to Belarus, the pandemic is stirring unrest. People are angry about economic hardships, and they see how the rich and well-connected go to the front of the queue for vaccinations, medical treatment and government help. They are angry that their leaders have not done a better job of containing the coronavirus. At the same time, people’s suffering has created a sense of solidarity which is fanning grievances that smouldered long before anyone had heard of covid-19.

In England, it looks like Boris Johnson’s gamble to unlock society will pay off. When Mr Johnson lifted restrictions on July 19th, many observers predicted disaster. More than a week of liberty later, without masks and with clubbing, cases are still falling. Indeed, daily case counts have fallen by roughly half since the rules were relaxed.

Meanwhile our Bagehot columnist observes that, with the return of summer parties, a sense of normality is returning to Westminster. A strange era in British politics could be coming to a close.

Among the many emergency measures introduced by state governments in America during the pandemic, one stood out for the jollity it heralded: a change in the law to allow bars and restaurants to sell cocktails-to-go. The change in states’ alcohol laws looks set to stay.

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Interesting Piece Of Trivia

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Gloria Vanderbilt’s Beekman Place Apartment Is for Sale


https://www.nytimes.com/2021/07/30/realestate/gloria-vanderbilt-home-sale.html?referringSource=articleShare

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Plastic Particles In Bottled Water

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Jimmy Elidrissi, Waldorf Bellhop for Five Decades, Dies at 74


https://www.nytimes.com/2021/07/27/nyregion/jimmy-elidrissi-dead.html?referringSource=articleShare

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Welcome To The Neighborhood

https://therealdeal.com/2021/07/23/robert-herjavec-buys-one57-condo-at-13m-discount/amp/

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Thrilled that Pauline and Alex Shender of Boca Raton came to play with us tonight. We are The Fountainhead Residency groupies.

Do You Know What Came Between Us And Our Calvins ?

The answer to the headline above is Calvin Klein himself. He caught Eliot and I poking around his property in the summer of 1983, a year after Whitney was born. We had just built a house in Montauk and we used to drive around the Hamptons looking for celebrities. We often went to Calvin’s private driveway to see if we could get a glimpse of his home.

For some reason, this time Eliot drove up the private road of Calvin’s East Hampton’s estate. Before we knew it, there was a car right behind us. It was Calvin himself. It was a single lane road so we didn’t know what to do. We just stopped. Calvin looked at us so we quickly made a very tight U turn and did our best to get past his car.

He just stared at us. He never said a word as we made our escape. He could have had us arrested. He must have seen Whitney in the back seat and figured we were just celebrity stalkers. We were, we are, we will continue to be.

The Dirt

Calvin Klein Sells East Hampton Estate in $85 Million Off-Market Deal

Calvin Klein East hampton house
Google/ASSOCIATED PRESS

Calvin Klein has left the building. Or, rather, he’s sold off the last of his properties in the Hamptons.

It was widely reported when Calvin Klein and second wife Kelly split up — unofficially in 1996 but not officially divorced until 2006 — that Kelly was keeping the beautiful oceanfront estate in East Hampton she and Calvin bought in 1987 for $3.6 million from the son of Juan Trippe, the founder of Pan American World Airways. And she did remain in residence.

However, deeds filed in Suffolk County show the nearly 8.5-acre spread has been sold, not by Kelly but by Calvin Klein in two contiguous off-market transactions that totaled $85 million. The bulk of the estate went for $75 million, while an undeveloped adjacent strip of land traded at $10 million. (The second transaction also shows Klein’s daughter, “Saturday Night Live” producer Marci Klein, as a signatory.) The buyers are shielded behind a couple of typically mysterious LLCs.

This is actually the second time in about a year that Calvin Klein has sold a Hamptons estate in an off-market deal valued at more than $80 million. In 2003, long after he and Kelly went their separate ways but still some years before their divorce was finalized, Calvin paid $30 million for an oceanfront mansion on Southampton’s Meadow Lane.

He demolished it, spent a fortune building a modern glass box in its place, and sold it to hedge funder Ken Griffin last year for a cool $84 million. And, perhaps not coincidentally, Kelly, a photographer and author who also has a home in Palm Beach, has just spent $15.9 million on a tiny waterfront cottage in nearby Sag Harbor, as first reported in the New York Post.

Calvin Klein House East Hampton

Photo : Out of copyright

The gorgeous house has an interesting history. In 1891, well-to-do single woman Laura Brevoort Sedgwick (1859-1907) hired noted Hamptons architect Joseph Greenleaf Thorp to build herself a house. Thorp is noted for having designed Grey Gardens, which, by the way, is quite close to this house, as well as another East Hampton mansion later owned by Chevy Chase.

Sedgwick soon met Henry A. James (1854-1929), and they married in the living room of this house. The couple hired Thorp to add on to the house, adding the windmill tower in the middle of the house in 1899. (Windmill houses are kind of a thing in the Hamptons. Many eccentric late 19th century houses in the area had fake windmills added to them; among them a cottage now owned by Robert Downey Jr.)

In 1935, aviation pioneer Juan Trippe (1899-1981), president of Pan Am Airlines, purchased the house and undertook significant renovations. The Kleins, who bought the house 52 years later from Trippe’s son, were only the third owners.https://a9dbd48badc672f9fee902c48955e6e9.safeframe.googlesyndication.com/safeframe/1-0-38/html/container.html

Calvin Klein House East Hampton

Photo : Google

The property consists of the main house, a pool that was added by the Kleins, and, because the property spans both sides of the street, a boathouse on Georgica Pond. Shortly after the Kleins acquired the estate, architect Thierry Despont was brought in to update and refresh the house, which was pictured in Vogue Decoration in 1992.

Even having sold these two huge estates in the Hamptons, Calvin is hardly homeless. Since the early 2000s he’s owned a 10,000-square-foot triplex penthouse in a Richard Meier-desgined building in New York’s West Village — the developers famously took Klein up in a helicopter so he could see exactly what the view would be like from the glass-walled aerie — and in 2015 he shelled out $25 million for a 9,300-square-foot contemporary mansion just above L.A.’s Sunset Strip.

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Too Important Not To Share

This may be years away from being a real cure but it’s nice to know we are going in this direction. Hurry up please.


A magnetic helmet shrunk a deadly tumor in world-first test

The user-friendly medical device can be operated at home.

Oncomagnetic Device

Houston Methodist Neurological Institute

We’ve seen helmets and AI that can spot brain tumors, but a new hard hat can actually treat them, too. As part of the latest neurological breakthrough, researchers used a helmet that generates a magnetic field to shrink a deadly tumor by a third. The 53-year-old patient who underwent the treatment ultimately passed away due to an unrelated injury. But, an autopsy of his brain showed that the procedure had removed 31 percent of the tumor mass in a short time. The test marked the first noninvasive therapy for a deadly form of brain cancer known as glioblastoma.

The helmet features three rotating magnets connected to a microprocessor-based electronic controller operated by a rechargeable battery. As part of the therapy, the patient wore the device for five weeks at a clinic and then at home with the help of his wife. The resulting magnetic field therapy created by the helmet was administered for two hours initially and then ramped up to a maximum of six hours per day. During the period, the patient’s tumor mass and volume shrunk by nearly a third, with shrinkage appearing to correlate with the treatment dose.null

The inventors of the device — which received FDA approval for compassionate use treatment — claim it could one day help treat brain cancer without radiation or chemotherapy. “Our results…open a new world of non-invasive and nontoxic therapy…with many exciting possibilities for the future,” said David S. Baskin, corresponding author and director of the Kenneth R. Peak Center for Brain and Pituitary Tumor Treatment in the Department of Neurosurgery at Houston Methodist Neurological Institute. Details of the procedure have been published in the peer-reviewed journal Frontiers in Oncology.

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ABC Reports That Zoom Calls Can Make You Demented!

Botox users getting younger after a year of Zoom meetings, doctors say

As cities around the world start to reopen after COVID-19 lockdowns, the effects of the pandemic are starting to show on people’s faces.

Experts in cosmetic medicine say they have begun to notice an uptick in Botox treatments among younger generations. They say people, particularly women, in their early 20s — aged from the pandemic and wearing less makeup than before — spent so much time looking at themselves during Zoom meetings that they started to notice their “imperfections,” and for the first time, turned to Botox and fillers.

“I would say that my average age of patients shifted down considerably this year, and it’s now early 20s,” Skinly Aesthetics founder Dr. Dmitriy Schwarzburg said. “And they’re coming not just for Botox, but for all kinds of procedures that they would otherwise consider at a much later point in their lives.”

Amy Shecter, the CEO of Ever/Body said, “The Zoom effect is real, and it has definitely been a catalyst for increased interest in cosmetic dermatology treatments.”

According to Stacy Garrity, a nurse practitioner at Ever/Body, many of their clients over the past year have admitted that they only started to notice their fine lines because of Zoom, and now that things are opening up, they’re anxious to get out of their quarantine funk and look and feel better.

The number of patients in their early to mid 20s “is a phenomenon that was not seen five years ago,” Garrity said.

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Art Is What We Have Common

Some of us are very talented, others are not. Some of us are older, others are not. Some of us are always creating, others are not. It doesn’t matter. We all love the Fountainhead Residency because it gives us a chance to meet others from around the world who just want to live in peace and appreciate the art of the possible.

This month, Fountainhead Residency partnered with Bas Fisher Invitational on Heat Exchange, a new reciprocal residency program between artists, curators, and artist-run spaces in Miami and Norway.

By bringing three Norwegian artists to Miami and sending three Miami artists to Norway, the program facilitates an exchange of artist-ambassadors who will immerse themselves in each other’s cultural landscape for one month. Visiting artists in both countries will hold conversations about how their practices incorporate civic engagement and artist advocacy, while they meet with local cultural stakeholders and conclude by presenting a public exhibition.

Heat Exchange is made possible with generous support through an International Cultural Partnerships Grant from the Miami-Dade County Department of Cultural Affairs, and residencies are made possible with the support of the Fountainhead Residency in Miami, and the Rogaland Kunstsenter in Stavanger. Hanan Benammar (New York)

Does your creativity spark after a random encounter? Then you should strike up a conversation with Hanan Bennamar, who finds her deepest inspiration in the chance conversations she stumbles into in her daily life. Joining us in Miami this month, Hanan is already fascinated by Miami’s prehistoric wildlife, and is eager to dive into research on the Cuban political diaspora. With her work aiming to spark conversations around power in language and the class orientations it often unveils, you might want to share your immigrant story with Hanan.Siri Borge (Stavanger, Norway)

If you’ve ever wondered what might happen if artists ran the world, then you might want to pay close attention to Siri Borge. A visual artist whose work is driven by political frameworks that keep humanity dependent on oil, Siri is running for office in her native Norway. Inspired by the strength of relentless women who came before her, Siri interweaves her political life with her artistic practice as though they are one. In Miami, she’s eager to take advantage of warmth, and explore the reptilian life in Miami as a continuation of a series she began in New Orleans. Ask Siri about how she manifests her unique vision into her work and her life.Máret Ánne Sara (Sápmi, Norway)

As the world is turning to ancestral wisdom for guidance in navigating the ills of the modern world, Máret Ánne Sara is hoping to share these gifts with those who are ready to receive them. An indigenous artist based in Norway, Máret investigates social and political issues from her native perspective, careful to channel her anger and frustration into art making. Are you curious about the indigenous philosophies that can alter how we honor the land? Join Máretas she dives into Miami’s local indigenous culture and tackle the issues you care about through her gaze.

IS CONDO LIVING SAFE?


Lying On The Beach’s Lois Whitman-Hess and Steve Greenberg talk with Jonathan McClintock, District Manager for KW Property Management & Consulting about the Surfside tragedy.


On June 24th— we were all shocked to learn that a condo tower in Surfside, Florida had collapsed overnight. We have since learned that 97 residents died in that collapse. It was tragedy that not only stunned South Florida— it’s stunned the nation.


AND it’s left many of us wondering “is our building safe?” “Are we next?” “Should we continue to live in a high rise?”


Jonathan oversees 14 Luxury Hi-Rise Condominium Buildings in Miami-Dade and Broward Counties — including one building in Surfside.


Jonathan talks about the structural fears of Hi-Rise living and what can residents do to insure our buildings are safe.

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